Epigallocatechin gallate – the most valuable polyphenol of green tea, with broad biological potential

What epigallocatechin gallate is

Epigallocatechin gallate, more often referred to by the abbreviation EGCG, is one of the most powerfully acting natural polyphenols found in the leaves of green tea. It is the main catechin responsible for the health-promoting properties of this drink, and its activity covers cellular protection, support for metabolism, an anti-inflammatory action and the regulation of many physiological processes. Contemporary science devotes an enormous number of studies to EGCG, because this compound shows the ability to modulate cellular pathways connected with regeneration, immunity and ageing.

How EGCG works at the cellular level

EGCG is a strong antioxidant that neutralises free radicals before they lead to damage to proteins, lipids or DNA. Its action is not limited, however, to the stabilisation of reactive oxygen species – epigallocatechin gallate also influences the signalling pathways responsible for cell proliferation, their regeneration and the immune response. This compound activates detoxifying enzymes, supports the repair of cellular structures and regulates the expression of genes responsible for the homeostasis of the body. EGCG also acts on the mitochondria, strengthening their energy capacity, which has a direct influence on the level of vital strength.

Anti-inflammatory and antioxidant action

Chronic inflammation is one of the main factors accelerating ageing and the development of lifestyle diseases. Epigallocatechin gallate inhibits the activity of pro-inflammatory mediators and reduces the production of inflammatory cytokines. At the same time it strengthens the antioxidant defence of the cells, thanks to which the body becomes more resistant to oxidative stress. EGCG also has a protective effect on the lipids of the cell membranes and stabilises their structure, which additionally strengthens the integrity of the tissues.

The influence of epigallocatechin gallate on metabolism

EGCG influences the regulation of glucose and fat metabolism. It increases thermogenesis, that is, the process of burning energy, and improves insulin sensitivity. This compound supports the control of body weight, reduces the absorption of lipids in the digestive tract and regulates the work of metabolic enzymes. Thanks to this, its action is important both in the prevention of obesity and in the regulation of the energy balance. These effects are particularly clearly visible when EGCG is used in a highly absorbable form.

Protection of the cardiovascular system

Epigallocatechin gallate supports the elasticity of the blood vessels and protects LDL lipoproteins against oxidation, which is one of the most important stages in the formation of atherosclerotic changes. EGCG supports normal blood pressure, reduces the level of oxidative stress in the vascular endothelium and improves the function of the cells responsible for proper blood flow. Regular supplementation with EGCG supports the health of the circulatory system on many levels.

Epigallocatechin gallate and skin health

The skin is particularly exposed to oxidative stress and UV radiation. EGCG supports the protection of skin cells against photochemical damage, increases repair processes and reduces inflammation. It also supports the production of collagen and stabilises the elastic fibres, which counteracts sagging and the ageing of the skin. EGCG is increasingly also being introduced into dermo-supplement formulas, where its action is more systemic.

The synergy of EGCG with other ingredients

Epigallocatechin gallate intensifies the action of many active substances. In combination with vitamin C it increases antioxidant protection, and with coenzyme Q10 and resveratrol it supports the mitochondria and slows down ageing processes. Combined with zinc or collagen, in turn, it improves the condition of the skin and supports regeneration processes. Synergy is one of the key elements thanks to which EGCG finds application in modern supplements.

The bioavailability of EGCG – why the form matters

A natural difficulty associated with EGCG is its low stability in the digestive tract. In contact with stomach acid and enzymes it breaks down quickly, which is why classic forms of supplements can be limited in terms of effectiveness. The solution lies in technologies that increase bioavailability – liposomal transport systems, nanoemulsions and encapsulation. Thanks to them EGCG is protected and its absorption increases many times over.

Epigallocatechin gallate in DWATRO Laboratories supplements

The DWATRO Laboratories brand uses EGCG in a form stabilised with the DWATRO®LIPtechnology, which considerably increases the bioavailability of epigallocatechin gallate. Thanks to phospholipid carriers EGCG is protected against degradation, transported to the cells better and acts more intensively at the mitochondrial and antioxidant level. In DWATRO Laboratories formulas EGCG is often combined with vitamin C, collagen, coenzyme Q10 or zinc, which strengthens the protective effect and supports the functioning of the skin, the vascular system and immunity.

The role of EGCG in neurological regeneration

Studies indicate that epigallocatechin gallate also acts on the cells of the nervous system. EGCG supports the protection of neurons against oxidative stress, improves the functioning of synapses and supports the mechanisms of neuroplasticity. Its ability to cross the blood–brain barrier means that it can influence cognitive processes, memory and concentration. This makes EGCG an interesting ingredient of formulas directed at brain health and the prevention of neurological ageing.

Summary

Epigallocatechin gallate is one of the most complex and valuable polyphenols found in nature. Its action covers the protection of cells against oxidative stress, the regulation of metabolism, support for the cardiovascular system, the improvement of skin elasticity and the protection of neurons. The effectiveness of EGCG depends to a large extent on the form of administration, which is why modern technologies such as the DWATRO®LIP liposomal systems considerably increase its bioavailability and stability. Epigallocatechin gallate is an ingredient of the future – one that combines natural origin with advanced biological and technological knowledge.

My name is Dorota Wątróbska-Świetlikowska, I am a pharmacist and a scientist holding a habilitated doctorate in pharmaceutical sciences. I decided to combine my scientific knowledge and my experience in order to create dietary supplements of the highest quality.

My passion and main area of research are submicron dispersion systems, such as submicron emulsions, liposomes and lipospheres. After obtaining my doctorate, I turned my attention to the practical aspects of parenteral nutrition, combining the needs of the patient with the possibilities of the pharmacist. What matters most to me is quality, safety and effectiveness , which is visible both in my scientific work and in my approach to creating the supplements of Dwatro Laboratories®.